Clinical Relevance of Notch1 in T-Cell Acute Lymphoblastic Leukaemia
نویسنده
چکیده
Notch1 signalling is an essential event in the thymopoiesis. Activating Notch1 mutations are frequently seen in T-Acute Lymphoblastic Leukaemia (T-ALL). Notch1 is mainly involved in the T cell proliferation, differentiation and apoptosis. The mutations in the Notch1 have been reported in more than 50% of T-ALL cases. The aberrant Notch1 signalling has a prominent role in the biology of T-ALL. Activating mutations of Notch1 were clinically significant in the molecular pathogenesis of T-ALL. The Crucial role of Notch1 in T cell lineage commitment and in the making of T-ALL paves the way to study Notch1 as a therapeutic target in the T-ALL therapy. In this review, the role of Notch1 in T-ALL, its signalling mechanism, Notch1 mutations, its impact on the disease prognosis and its therapeutic significance has been discussed to reiterate Notch1 as a molecular marker in T-ALL.
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تاریخ انتشار 2013